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显微镜科学与教学知识中心

显微镜科学与教学知识中心

显微镜科学与教学知识中心

徕卡显微系统的知识库提供有关显微镜学科的科学研究和教学材料。内容旨在对显微镜初学者、有经验的显微镜操作实践者和使用显微镜的科学家在他们的日常工作和实验有所帮助。这里有探索交互式教程和应用笔记，你可以找到你需要的显微镜的基础知识以及前沿技术——快来加入徕卡显微知识社区，分享您的专业知识！
Zebrafish Whole Brain imaging with Leica SP8 spectral confocal laser scanning microscope

斑马鱼大脑高分辨率全器官成像

结构信息是理解复杂生物系统的关键，而脊椎动物的中枢神经系统是最复杂的生物结构之一。要想从发育中的斑马鱼身上分离出一个完整的大脑，我们需要覆盖大约10平方毫米的区域，深度在毫米范围内。通常，低倍透镜不能提供足够的分辨率来揭示神经组织中复杂结构之间的相互作用。此外，由于散射过程，使用共聚焦显微镜在致密生物组织内成像深度通常限制在大约10微米。

Improving RNA Analysis with Laser Microdissection

Parkinson’s disease is a progressive neurodegenerative disorder connected with cell death of dopamine-releasing neurons in the brain. Differences in gene expression between individual…

How to improve your Alzheimer Protein Analysis with Laser Microdissection

Brain Research: Collect pure starting material for proteomics - Improve your workflow with Laser Microdissection - Many brain diseases result from protein malfunction, misfolding and agglutination.…
C. elegans

Studying Caenorhabditis elegans (C. elegans)

Find out how you can image and study C. elegans roundworm model organisms efficiently with a microscope for developmental biology applications from this article.

The Morbus Parkinson Puzzle

A characteristic sign of M. Parkinson is the deterioration of dopaminergic neurons in the mid-brain, specifically in the substantia nigra (SN, black substance). Different causes and forms of this…
Snapshot from a time lapse of a calcium imaging experiment using the ratiometric calcium indicator Fura-2.

Ratiometric Imaging

Many fundamental functions of a cell strongly depend on delicate, but nevertheless dynamic balances of ions (e.g. calcium, magnesium), voltage potentials and pH between the cell’s cytosol and the…

New Standard in Electrophysiology and Deep Tissue Imaging

The function of nerve and muscle cells relies on ionic currents flowing through ion channels. These ion channels play a major role in cell physiology. One way to investigate ion channels is to use…
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