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大脑的形状:阿尔茨海默病的空间生物学
阿尔茨海默病(AD)是一种神经退行性疾病,也是导致晚年认知障碍的常见原因。阿尔茨海默病的特征是出现含β-淀粉样蛋白的斑块和含磷酸化 tau 的神经纤维缠结。目前尚缺乏治疗和预防AD的有效疗法。我们将Cell DIVE与Cell Signaling Technology的抗体结合使用,检查了AD的突触过程并从空间上确定了神经胶质细胞和神经元等细胞,证明了超多标免疫荧光成像技术可用于探测AD大脑。
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Macroscale to Nanoscale Pore Analysis of Shale and Carbonate Rocks
Physical porosity in rocks, like shale and carbonate, has a large effect on the their storage capacity. The pore geometries also affect their permeability. Imaging the visible pore space provides…
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Porous Ceramics - Sample Preparation for SEM
Application Note for Leica EM RES102 - Ceramic membrane filters with pore sizes down to a few nanometres must be investigated in cross-section with regard to the structure of the pores. The smallest…
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Paper Samples - Sample Preparation for SEM
Application Note for Leica EM RES102 - A coated paper sample has been prepared with ion beam slope cutting in order to test the procedure with regard to its applicability. With the use of ion beam…
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细菌实验方案 - 对大肠杆菌样本实施临界点干燥以进行SEM分析
徕卡EM CPD300的应用文档 - 生命科学研究,对大肠杆菌样本实施临界点干燥后,进行铂/钯金属镀膜,后用SEM拍摄微观形貌,将样本放入一个滤盘中(孔径:16-40μm),置入滤盘和多孔样品架内。在含有培养基的琼脂上培养真菌和细菌,为期3天。选取部分细菌菌落。
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Ion Beam Polishing of Sample Surfaces - Sample Preparation for SEM
Application Note for Leica EM RES102 - Ion milling can be used to reduce the roughness of sample surfaces. Small angles less than 6° with respect to the sample surface are necessary. The high voltage…
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Epoxy Resin Embedding of Animal and Human Tissues for Pathological Diagnosis and Research
Application Note for Leica EM AMW - The tissues were fixed in the modified Karnovsky fixative generally by immersion overnight (at minimum 4h at room temperature). Then pieces of approx. 1mm3 were cut…
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Human Blood Cells Protocol
Application Note for Leica EM CPD300 - Life Science Research. Species: Human (Homo sapiens)
Critical point drying of human blood with subsequent platinum / palladium coating and SEM analysis.