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显微镜科学与教学知识中心

显微镜科学与教学知识中心

显微镜科学与教学知识中心

徕卡显微系统的知识库提供有关显微镜学科的科学研究和教学材料。内容旨在对显微镜初学者、有经验的显微镜操作实践者和使用显微镜的科学家在他们的日常工作和实验有所帮助。这里有探索交互式教程和应用笔记，你可以找到你需要的显微镜的基础知识以及前沿技术——快来加入徕卡显微知识社区，分享您的专业知识！
[Translate to chinese:] Spheroid stained with Cyan: Dapi nuclear countertain; Green AF488 Involucrin; Orange AF55 Phalloidin Actin; Magenta AF647 CK14.

基于人工智能的表型药物筛查解决方案

本次网络研讨会将全面介绍使用三维细胞培养进行表型药物筛选所遇到的问题、可能的解决方案及规划与执行策略。

免疫细胞在组织样品中的共聚焦成像

在本次网络研讨会中，您将探索如何使用共聚焦显微镜对组织样品进行10色成像，并了解这一技术如何有助于评估皮肤免疫状况。

Virtual Reality Showcase for STELLARIS Confocal Microscopy Platform

In this webinar, you will discover how to perform 10-color acquisition using a confocal microscope. The challenges of imaged-based approaches to identify skin immune cells. A new pipeline to assess…
Wt1b-positive myocardial cell adopting an epicardial cell morphology.

Wt1 Genes Can Induce a Cardiomyocyte to Epicardial-like Cell Fate Transition

From this study, it was concluded that Wt1 plays a yet undescribed role for cardiomyocyte differentiation by repressing chromatin opening at specific genomic loci and that sustained ectopic expression…
[Translate to chinese:] Dual color volume rendering of Drp1 oligomers (green) and mito OM (red) in a live U2OS cell

多色四维超分辨光片显微镜

人工智能显微术研讨会主要关注和讨论显微术和生物医学成像领域的最新人工智能技术和工具。在该科学演示中，Yuxuan Zhao展示了如何通过渐进式深度学习策略并结合“双环调制的SPIM”设计改善活细胞中的细胞器三维成像。
3D-volume-rendered light-sheet microscope image of a spheroid showing depth coding in different colors.

Imaging of Anti-Cancer Drug Uptake in Spheroids using DLS

Spheroid 3D cell culture models mimic the physiology and functions of living tissues making them a useful tool to study tumor morphology and screen anti-cancer drugs. The drug AZD2014 is a recognized…

透明介质对组织透明度和收缩的影响

本研究通过比较新鲜解剖的双翅目昆虫脑与其透明化处理后的等效物，全面评估了不同透明化介质对组织透明度和收缩率的影响。组织透明化处理结合光片显微技术，已成为全器官三维成像和定量的强大工具。由于组织透明化处理有助于在亚细胞水平上对完整组织进行光学成像，它有潜力揭示如大脑等复杂器官以前未见的细节。为了对厚样本进行高分辨率成像，透明化介质需要与高数值孔径（NA）物镜使用的浸没液具有匹配的高折射率。这一点对于…

Understanding Motor Sequence Generation Across Spatiotemporal Scales

We have developed a microscopy-based pipeline to characterize a developmentally critical behavior at the pupal stage of development, called the ecdysis sequence. We study brain-wide neuronal activity…
Schematic graph of the light path in a Spalt-Ultramikroskop.

Confocal and Light Sheet Imaging with STELLARIS DLS

Optical imaging instrumentation can magnify tiny objects, zoom in on distant stars and reveal details that are invisible to the naked eye. But it notoriously suffers from an annoying problem: the…
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