生命科学研究

在生命科学研究中心，您可以掌握最新的关于先进显微镜、成像技术、电镜样品制备和图像分析的前沿应用和创新，涵盖的主题包括细胞生物学、神经科学和癌症研究。希望在这里可以帮助您提升研究能力和精进显微镜在各个科学领域实际应用，并了解徕卡如何通过精确的可视化、图像解读和推进研究进展来赋能您的工作。

These images illustrate the need for multiple z-slices to capture all gH2Ax foci in a given cell and get an accurate count.

Development and Derisking of CRISPR Therapies for Rare Diseases

This on-demand presentation by Dr. Fyodor Urnov and Dr. Sadik Kassim, originally delivered at ASGCT 2025, focused on a critical challenge in genetic medicine: how to scale CRISPR therapies from…

Trichomonas parasite in mouse gut, rOTO Embedding and serial sections for array tomography imaging. Sample courtesy Isabelle Guerin-Bonne, Low Kay En, Electron Microscopy Unit, Yong loo Lin School of Medicine, National University of Singapore

Integrated Serial Sectioning and Cryo-EM Workflows for 3D Biological Imaging

This on-demand webinar explores how integrated tools can support electron microscopy workflows from sample preparation to image analysis. Experts Andreia Pinto, Adrian Boey, and Hoyin Lai present the…

3D high-plex imaging in cancer immunology. Overview of a pancreatic tumor section in mouse model, labeled with 15 markers and imaged in one go using STELLARIS with SpectraPlex. (https://www.nature.com/articles/d42473-024-00260-7)

How to Streamline High-Plex Imaging for 3D Spatial Omics Advances

In this webinar, Dr. Julia Roberti and Dr. Luis Alvarez from Leica Microsystems introduce SpectraPlex, a new functionality integrated into the STELLARIS confocal platform for high-plex 3D spatial…

Large volume computational clearing processed Thunder image of human pancreatic islet organoid. Cells segmented using Segment By Example tool, automatically phenotyped, and color-coded based on phenotypes in Aivia. Image courtesy of the Matthias von Herrath Lab, La Jolla Institute of Immunology, La Jolla, CA.

利用人工智能图像分析工具更快、更轻松地获得洞察力

了解 Aivia 如何通过快速设置、准确的人工智能检测和简便的批量处理功能，帮助科学家简化图像分析。

Transfection using the Uncommon Bio reprogramming system. Image acquired using the THUNDER Imager 3D Cell Culture with THUNDER Large Volume Computational Clearing (LVCC) applied. Image courtesy of Samuel East, Uncommon Bio.

利用新型可扩展的干细胞培养设计未来

具有远见卓识的生物技术初创企业 Uncommon Bio 正在应对世界上最大的健康挑战之一：食品可持续性。在这次网络研讨会上，干细胞科学家塞缪尔-伊斯特（Samuel East）将展示他们如何使细胞农业的干细胞培养基既安全又经济可行。了解他们如何将培养基成本降低 1000 倍，并开发出不含动物成分、食品安全的 iPSC 培养基。

Complete camera overview of EM grid recorded with 3 channels. Inserts displaying the positions, where superresolved 3D confocal images were recorded. 3D renderings of these positions are shown in the zoomed inserts. Fluorescence channels (nuclei by Hoechst, blue; mitochondria by MitoTracker Green, green; lipid Droplets by Bodipy and Crimson Beads, red). Width of a grid square is 90 ?m, width of a grid bar is 35 ?m. Samples kindly provided by Ievgeniia Zagoriy, Mahamid-Group, EMBL Heidelberg, Germany.

从显微镜到电镜：完整的冷冻光电联用工作流程

在题为“多模态玻璃化征程，从实验台到电子显微镜的冷冻关联工作流程”的网络研讨会上，专家团队（Edoardo D'Imprima、Zhengyi Yang、Andreia Pinto 和 Martin…

Developing embryos of different species at different stages during the elongation of their posterior body axis, from left to right in developmental time. The labelled regions in red depict a region of undifferentiated cells called the tailbud, with the corresponding region generated from that tissue shaded in grey. Upper row: lamprey; middle row: catshark; bottom row, zebrafish. This figure has been adapted from the following publication: Steventon, B., Duarte, F., Lagadec, R., Mazan, S., Nicolas, J.-F., & Hirsinger, E. (2016). Species tailoured contribution of volumetric growth and tissue convergence to posterior body elongation in vertebrates. Development, 2016. 143(10):1732-41

如何研究胚胎发育中的基因调控网络

欢迎参加由 Ben Steventon 博士与 Andrea Boni 博士主讲的点播网络研讨会，探索光片显微镜如何革新发育生物学研究。这项先进成像技术能对三维样本进行高速、大体积的活体成像，且光毒性低。通过用户案例了解光片显微镜如何深化我们对肠道类器官与脑类器官发育的认知，并深入解析徕卡显微系统 Viventis Deep 显微镜的技术原理及其在长时间成像中的应用。

GLP-1 and PYY localized to distinct secretory pools in L-cells.

前沿成像技术用于 GPCR 信号传导

通过这个按需网络研讨会，提升您的药理研究，了解 GPCR 信号传导，并探索旨在理解 GPCR 信号如何转化为细胞和生理反应的尖端成像技术。发现领先的研究，扩展我们对这些关键通路的认识，以寻找新的药物发现途径。

Stripe assay performed on a THUNDER Imager Cell. Courtesy of Maria Carrasquero Ordaz, University of Oxford.

揭示神经元迁移的分子奥秘

研究发育中大脑神经元向生态位迁移可采用多种方法。在本场研讨会中，牛津大学的专家们将展示他们用于阐明神经发育期间神经元向皮层功能层迁移的分子机制的显微技术与实验方法。理解这些过程将有助于更深入地认识健康大脑的发育机制，并可能为神经发育障碍提供更优治疗方案。

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