Luis Alvarez , Dr.

Luis Alvarez

Dr. Luis Alvarez studied physical chemistry at the Université Paris-Sud XI in Orsay where he worked on molecular quantitative imaging in live cells. He concentrated on fluorescence lifetime imaging and the effects of reactive oxygen species (ROS) on fluorescent proteins. In 2010, he moved to Dublin where he worked on host-pathogen interactions at University College Dublin and the National Children Research Centre. He studied how mucosal immunity uses ROS to respond to bacterial pathogen infections. During this time, he developed 3D infection models from ex-vivo organ cultures and organoids. In 2016, he moved to the University of Oxford where he developed advanced quantitative imaging approaches to study host-pathogen interactions. This work centered on the understanding of HIV and EBOLA entry mechanisms into cells. He joined Leica Microsystems in 2019 as a product application manager for functional imaging.

Spectral separation of 11 fluorophores coupled to polystyrene beads on a STELLARIS confocal system.

通过 11 种颜色的光谱分离实现超多标记

荧光显微镜是生命科学研究的基本工具,随着细胞组织和模式生物多色标记策略的发展而不断发展和成熟。分子特异性标记多种物种的能力需要适当的工具来识别样品中的多种荧光标签。严格分离多个标签对于获得有意义的成分、丰度、结构和功能读数至关重要。这种所谓的超多标技术在揭示组织组织、癌症进展、肿瘤免疫相互作用和传染病机制等关键方面已变得十分突出。

TauInteraction——TauSense新成员,研究分子间相互作用

荧光显微镜是生命科学的重要研究工具之一,用于观察细胞结构和功能。荧光显微镜的一个关键优势在于能够识别多个目标,并能够观察他们之间的相互作用。
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