Carolina Borges-Merjane , Dr.

Carolina Borges-Merjane

Dr. Carolina Borges-Merjane was born in Brazil and studied Biochemistry and Cell Biology at the University of California San Diego (U.S.A.). After obtaining her Bachelor of Science, she joined the lab of Laurence Trussell at the Vollum Institute and Oregon Health & Science University (U.S.A) for her PhD thesis. For her dissertation, she studied glutamatergic synaptic transmission from mossy fiber terminals to unipolar brush cells of the cerebellum and dorsal cochlear nucleus, with electrophysiology and confocal microscopy.

After finishing her PhD in 2015, she joined the lab of Professor Peter Jonas at the Institute of Science and Technology (IST) Austria, where she was a Marie-Curie Individual Fellow, EMBO Long-Term Fellow and FWF Elise Richter Fellow. She is using electrophysiology and electron microscopy with optogenetics, correlating function and structure, to study synaptic transmission properties under basal and plasticity states, at the hippocampal mossy fiber to CA3 pyramidal neuron synapse in hippocampus.

使用增强功能电子显微镜研究大脑切片中的突触

神经科学的一个基本问题就是突触的结构与其功能特性之间有何关系?过去几十年,电生理学揭示了突触传递机制,而电子显微镜(EM)深入探索了突触形态。用于关联突触生理学和超微结构的方法可以追溯到20世纪中叶。目标是获得突触传递的快照,即捕获电子显微照片中的动态过程。
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